HEALEY PHARMA (UK) LIMITED
HEALEY PHARMA (UK) LIMITED
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PIROXICAM 20 MG/2ml INJECTION
COMPOSITION:
Each 2ml ampoule contains 20 mg piroxicam.
PHARMACOLOGICAL ACTION:
Piroxicam has analgesic, anti-inflammatory and antipyretic properties, and is used in the treatment of rheumatoid arthritis and other rheumatic disorders. Piroxicam acts as an inhibitor of prostaglandin biosynthesis.
Piroxicam is completely absorbed after oral administration: peak concentrations in plasma occur within two to four hours. Neither food nor antacids alter the rate or extent of absorption.
INDICATIONS:
Piroxicam is indicated for a variety of conditions requiring anti-inflammatory and/or analgesic activity, such as rheumatoid arthritis, osteo-arthritis (arthrosis, degenerative joint disease), ankylosing spondylitis, acute musculoskeletal disorders and acute gout.
CONTRA-INDICATIONS:
Piroxicam should not be used in those patients who have previously shown a hypersensitivity to the drug and patients who have hepatic dysfunction. Piroxicam should be used with caution in patients with a history of gastro-intestinal haemorrhage, ulcers or aspirin sensitivity.
WARNINGS:
Use in children:Piroxicam is not recommended for children.
INTERACTIONS:
Piroxicam should not be used in patients on coumarin-type anticoagulants.
Piroxicam increases plasma lithium levels.
PREGNANCY AND LACTATION:
Piroxicam should not be used by patients who are pregnant.
The safety of Piroxicam use during pregnancy or during lactation has not yet been established. Piroxicam inhibits prostaglandin synthesis and release by an effect on prostaglandin biosynthetase. This effect has been associated with an increased incidence of dystocia and delayed parturition in pregnant animals when drug administration was continued into late pregnancy.
DOSAGE AND DIRECTIONS FOR USE:
Adult : 1 Ampoule every day,intramuscular injection.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
In view of the product’s inherent potential to cause fluid retention, heart failure may be precipitated in some compromised patients.
Gastrointestinal symptoms are the most commonly encountered side-effects. Long-term administration of doses higher than 30 mg daily carries an increased risk of gastrointestinal side-effects.
Peptic ulceration and gastrointestinal bleeding have been reported with Piroxicam. Drug administration should be closely supervised in patients with a history of upper gastro-intestinal disease.
STORAGE INSTRUCTIONS:
Store below 25°C. Protect from light. Keep out of reach of children.