HEALEY PHARMA (UK) LIMITED
HEALEY PHARMA (UK) LIMITED
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CLOXACILLIN 250 MG Capsules
COMPOSITION:
Each capsule contains cloxacillin sodium equivalent to 250 mg or 500 mg cloxacillin.
PHARMACOLOGICAL ACTION:
Cloxacillin is a semi-synthetic penicillin, resistant to penicillinase, and is therefore active against penicillinase-producing staphylococci.
Cloxacillin is in general less effective against organisms susceptible to benzylpenicillin, such as streptococci, pneumococci and non-penicillinase-producing staphylococci, and is not useful against gram-negative bacteria.
INDICATIONS:
Cloxacillin is indicated for the treatment of infections due to penicillinase-producing staphylococci that are resistant to benzylpenicillin. It is used against gram-positive staphylococcus aureus in:
| skin and soft tissue infections, e.g. abscesses, cellulitis. | |
| pneumonia | |
| endocarditis | |
| osteomyelitis |
CONTRA-INDICATIONS:
Cloxacillin should not be given to patients with a history of penicillin allergy or administered to neonates 0born
of mothers hypersensitive to penicillin.
Patients allergic to cephalosporins may also be allergic to penicillins.
Cloxacillin is incompatible with aminoglycosides, tetracyclines, erythromycin and polymyxin B.
WARNINGS:
Use with caution in patients with a known history of allergy to penicillins.
When administered to a patient with penicillin sensitivity anaphylactic shock may occur. Adrenaline, corticosteroids and antihistamines should be used to treat anaphylaxis.
Due to the variability in intestinal absorption, oral administration is not a suitable substitute for the parenteral treatment of serious infections.
DOSAGE AND DIRECTIONS FOR USE:
| Adults: | One 500 mg capsule six hourly, administered one hour before meals. |
| Children: (2-10 yrs) |
One 250 mg capsule six hourly, administered one hour before meals. |
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Sensitivity reactions may include skin rashes, angioedema, bronchospasm, serum sickness and anaphylaxis, 0and sometimes death within minutes. Treatment with adrenaline, corticosteroids, aminophyllin or antihistamines may be necessary. A generalised sensitivity reaction can develop within a few hours or weeks of commencing treatment, including urticaria, fever, joint pains and eosinophilia. Other allergic reactions include exfoliative dermatitis and maculopapular rashes, interstitial nephritis and vasculitis. Haemolytic anaemia, leucopenia, prolonged bleeding time and defective platelet function can occur.
STORAGE INSTRUCTIONS:
Store in a dry place below 25°C.