HEALEY PHARMA (UK) LIMITED
HEALEY PHARMA (UK) LIMITED
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Hyoscine Butylbromide Tablets
COMPOSITION:
Each tablet contains 10 mg Hyoscine Butylbromide
PHARMACOLOGICAL ACTION:
Hyoscine butylbromide is a quaternary ammonium anticholinergic agent, the peripheral effects of which are similar to those of atropine, but weaker and of shorter duration.
INDICATIONS:
Hyoscine butylbromide is used in the treatment of conditions associated with gastro-intestinal spasm.
CONTRA-INDICATIONS:
Enlarged prostate. Closed angle glaucoma, or narrow angle between the iris and cornea as hyoscine increases intra-ocular pressure.
WARNING:
The safe use of Hyospasmol is contentious in patients with porphyria.
DOSAGE AND DIRECTIONS FOR USE:
Adult dose:
| Tablets: | 20 mg four times daily. |
Paediatric dose:
| Tablets: | Children 1 - 3 years: 5-10 mg three times daily. |
| Children 3 - 6 years: 10 mg three times daily. | |
| Children 6 - 12 years: 10-20 mg three times daily. |
SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Dryness of the mouth, with difficulty in swallowing and talking, thirst, dilatation of the pupils (mydriasis) with loss of accommodation (cycloplegia) and photophobia, flushing and dryness of the skin, transient bradycardia followed by tachycardia, with palpitations and arrhythmias, and urinary urgency, difficulty and retention, as well as reduction in the tone and motility of the gastro-intestinal tract leading to constipation. Occasionally vomiting, giddiness and staggering may occur.
Retrosternal pain may occur due to increased gastric reflux.
Antimuscarinic agents should be used with caution in conditions characterised by tachycardia such as thyrotoxicosis, cardiac insufficiency or failure, and in cardiac surgery, where it may further accelerate the heart-rate. Care is required in patients with acute myocardial infarction as ischaemia and infarction may be made worse.
The effects of antimuscarinic agents may be enhanced by the concomitant administration of other medicines with antimuscarinic properties, such as amantadine, some antihistamines, butyrophenones and phenothiazines, and tricyclic antidepressants. The reduction in gastric motility caused by antimuscarinic agents may affect the absorption of other medicines.
STORAGE INSTRUCTIONS:
Store below 25°C. Protect from light and moisture.
KEEP OUT OF REACH OF CHILDREN.