HEALEY PHARMA (UK) LIMITED
HEALEY PHARMA (UK) LIMITED
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Cimetidine Tablets 200MG
COMPOSITION:
Each Tablet contains 200 mg cimetidine.
PHARMACOLOGICAL ACTION:
Cimetidine inhibits basal (fasting) and nocturnal gastric acid secretion and reduces pepsin output by competitive inhibition of the action of histamine at the histamine H2-receptors of the parietal cells. Cimetidine also inhibits gastric secretion elicited by muscarinic agonists or by gastrin, although this effect is not always complete. It reduces both the volume of gastric juice secreted and its hydrogen ion concentration.
INDICATIONS:
Duodenal ulcer
Gastric ulcer
Reflux oesophagitis
Upper gastrointestinal bleeding
Hypersecretory states associated with systemic mastocytosis or basophilic leukemia with hyperhistaminemia or Zollinger - Ellison syndrome.
CONTRA-INDICATIONS:
Sensitivity to cimetidine or related agents.
Should not be administered to pregnant or lactating patients.
DOSAGE AND DIRECTIONS FOR USE:
Since CIMETIDINE may not always give immediate symptomatic relief, antacids should be made available to patients as needed for relief of pain.
Usual dose: 200 mg, or if necessary 400 mg three times a day with meals and 400 mg at bedtime.
Clinical experience with CIMETIDINE in children is limited. Not recommended for use in children.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Diarrhoea, dizziness, tiredness, headache and rashes have been reported.
Reversible confusional states, especially in the elderly or in seriously ill patients such as those with renal failure, have occurred.
Cimetidine has an anti-androgenic effect and gynaecomastia and impotence have occurred in men receiving relatively high doses for conditions such as the Zollinger - Ellison syndrome.
Allergic reactions, arthralgia and myalgia, blood disorders including agranulocytosis or granulocytopenia and thrombocytopenia, interstitial nephritis, hepatotoxicity and pancreatitis have been reported.
STORAGE INSTRUCTIONS:
Store below 25°C. Protect from light. Keep tightly closed, out of reach of children.